Registration Dossier
Registration Dossier
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EC number: 212-079-0 | CAS number: 760-23-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: MIGRATED DATASET. Original reference not yet available.
Data source
Reference
- Title:
- No information
- Author:
- Du Pont, Haskell Laboratory for Toxicology and Industrial|Medicine: Inhalation studies - two-week subacute, Report No.|364-75 (1975), NTIS/OTS 0533725
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: No data
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 3,4-dichlorobut-1-ene
- EC Number:
- 212-079-0
- EC Name:
- 3,4-dichlorobut-1-ene
- Cas Number:
- 760-23-6
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 3,4-dichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 3,4-dichlorobut-1-ene
- Analytical purity: 98.74%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD and Long-Evans
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on inhalation exposure:
- Liquid 3,4-DCB-1 was delivered at a constant rate by a syringe pump into a heated (~ 110° C) round-bottom flask. Air metered into the flask carried the resulting vapours into a glass 30-liter chamber containing the test animals. Samples of the chamber atmosphere were taken at hourly intervals during exposure by trapping 3,4-DCB-1 in hexane and analyzing the resulting mixture by gas chromatography. Half of the animals were sacrificed and autopsied at 1 day after the last exposure; the remaining animals were sacrificed after the recovery period.
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 6 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20 or 200 ppm (104 or 1037 mg/m³)
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 14 days
Results and discussion
Results of examinations
- Details on results:
- 200 ppm appeared to have a slight effect on both ChR-CD and Long-Evans rats. This was evidenced by an increased liver-to-body weight ratio and changes in liver cell morphology. These effects were not present in the ChR-CD rats after a 14-day recovery period, but the increased liver-to-body weight did persist in 2/3 Long-Evans rats 14 days post-exposure.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 ppm
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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