Registration Dossier
Registration Dossier
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EC number: 500-018-3 | CAS number: 9005-64-5 1 - 6.5 moles ethoxylated
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR Database
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- Dermwin v2.01 (Q)SAR database report
Test material
- Reference substance name:
- Sorbitan monolaurate, ethoxylated
- EC Number:
- 500-018-3
- EC Name:
- Sorbitan monolaurate, ethoxylated
- Cas Number:
- 9005-64-5
- Molecular formula:
- Molecular formula cannot be given as substance is a mixture.
- IUPAC Name:
- Sorbitan monolaurate, ethoxylated (1-6.5 moles ethoxylated)
Constituent 1
Results and discussion
- Absorption in different matrices:
- Dermal absorption of the test substance was predicted to be very low with an estimated dermal permeability coefficient (Kp) of 0.000826 (1 EO) and 2.18 e-006 (7 EO) cm/hr and a dermal absoprtion rate of 0.00034 mg/cm²/h (=0.0000861 mg/cm²/event, 1 EO) and 0.0000024 mg/cm²/h (=0.00000064 mg/cm²/event, 7 EO).
Applicant's summary and conclusion
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