Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1962
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only available, data not accessible by the registrant

Data source

Reference
Reference Type:
secondary source
Title:
Initial submission to US EPA regarding the toxicity of Bromoaceti acid in rats and rabbits
Author:
US EPA
Year:
1992
Bibliographic source:
US EPA National Technical Information Service (NTIS), microfiche No. OTS0555280, Doc ID 88-92-0008963

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no details given
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bromoacetic acid
EC Number:
201-175-8
EC Name:
Bromoacetic acid
Cas Number:
79-08-3
Molecular formula:
C2H3BrO2
IUPAC Name:
2-bromoacetic acid
Test material form:
solid: crystalline
Details on test material:
solid moistened with water

Test animals

Species:
rabbit
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
water

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 59.9 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no details reported
Clinical signs:
severe skin irritation reported

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information acute class 3 Criteria used for interpretation of results: EU
Conclusions:
The data are of limited reliability as no details are given, but support the expected effects from a corrosive substance and the current classification as acute toxic class 3 by the dermal route.
Executive summary:

The data are of limited reliability as no details are given, but support the expected effects from a corrosive substance and the current classification as acute toxic class 3 by the dermal route.