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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (comparable to guidelines/standards). Data were audited by QAU but no reference to GLP standard. Original report not available. Data, reliability and rationale as cited in OECD SIDS (2006).

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1983
Reference Type:
secondary source
Title:
OECD SIDS Hydroxypropyl acrylate, CAS No. 25584-83-2.
Author:
OECD SIDS
Year:
2006
Bibliographic source:
OECD SIDS for SIAM 20, UNEP Publications, October 2006.

Materials and methods

Principles of method if other than guideline:
Acute eye irritation
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Rocryl 430 (Hydroxypropyl acrylate)
- Analytical purity: 97 %

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
Twenty to 30 seconds after instillation, three of the nine animals had their eyes flushed with water for approximately 60 seconds.
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
9
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing: yes, in three of nine animals
- Time after start of exposure: 30 sec


Results and discussion

Any other information on results incl. tables

Irritation of the cornea, iris and conjunctivae with opacification, and blood vessel encroachment of the cornea, were observed throughout the 21-day observation period. The iris was unscorable due to the density of the opacity. The compound was regarded as severely eye damaging on the basis of the duration of the ocular effects.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria