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EC number: 241-460-4 | CAS number: 17439-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Remarks:
- and other
- Type of information:
- other: review
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR summairses a number of non-Guideline studies
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Sodium fluoride is water soluble and will rapidly dissociate under the aqueous conditions of the test to form sodium and fluoride ions. The toxicity of sodium fluoride is essentially due to fluoride ions and therefore is appropriate for read-across to KF. - Analytical monitoring:
- not specified
- Test organisms (species):
- other: various
- Test type:
- static
- Water media type:
- freshwater
- Remarks on exposure duration:
- see details
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 83 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Chlomonas paramaecium
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 101 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Entosiphon sulcatum
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of acid formation from glucose
- Remarks on result:
- other: Eschericia coli
- Duration:
- 20 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Uronema parduczi
- Duration:
- 28 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibition of feed uptake
- Remarks on result:
- other: Microregma heterotoma
- Duration:
- 16 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 231 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Pseudomonas putida
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC values of between 7.1 -226 mg F/L are reported.
- Executive summary:
The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 -226 mg F/L are reported.
- Endpoint:
- activated sludge respiration inhibition testing
- Remarks:
- and other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, hydrogen and titanium ions upon dissolution in the environment. However, hydrogen and titanium ions do not remain as such in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
sodium fluoride (CAS 7681-49-4)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)
3. ANALOGUE APPROACH JUSTIFICATION
The hydrogen ion attaches to a hydroxide ion to form a water molecule. The analysis of dissolved titanium levels in aquatic toxicity test solutions for algae, daphnia and fish according to OECD 201, 202 and 203 (Schlechtriem, 2013a, b; Teigeler, 2013) indicates that up to a loading of 100 mg/L dipotassium hexafluorotitanate, very low levels of titanium (often < 10% or even 5%) remain in solution at environmentally relevant pH while nearly all of the fluoride (often more than 95 %) could be recovered. Thus, regarding the environmental fate and toxicity of dihydrogen hexafluorotitanate, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across to potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion is justified. The lowest available NOEC of 7.1 mg F/L results in a NOEC for microbial toxicity of 10.2 mg/L dihydrogen hexafluorotitanate.
4. DATA MATRIX
see attached read-across statement in section 13.2 - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 83 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Chlomonas paramaecium
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 101 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Entosiphon sulcatum
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of acid formation from glucose
- Remarks on result:
- other: Eschericia coli
- Duration:
- 20 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Uronema parduczi
- Duration:
- 28 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibition of feed uptake
- Remarks on result:
- other: Microregma heterotoma
- Duration:
- 16 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 231 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Pseudomonas putida
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC values of between 7.1 -226 mg F/L are reported.
- Executive summary:
The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 -226 mg F/L are reported.
Referenceopen allclose all
The EU RAR reports NOEC values of between 7.1 -226 mg F/L.
The EU RAR reports NOEC values of between 7.1 -226 mg F/L.
Description of key information
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of microbial toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below). The lowest available NOEC of 7.1 mg F/L for toxicity of fluoride to Uronema parduszi results in a NOEC for microbial toxicity of 16.74 mg/L dihydrogen hexafluorotitanate.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 16.74 mg/L
Additional information
Dihydrogen hexafluorotitanate
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of microbial toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below). The lowest available NOEC of 7.1 mg F/L results in a NOEC for microbial toxicity of 16.74 mg/L dihydrogen hexafluorotitanate.
Sodium fluoride
The guideline-compliant Bayer study reports a 3 -hour NOEC of 510 mg/L for activated sludge. The EU RAR summarises and reviews the other available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 - 226 mg/L are reported.
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