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Diss Factsheets

Ecotoxicological information

Toxicity to soil microorganisms

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Administrative data

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Endpoint:
toxicity to soil microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Recent review of published work on fluoride ions.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline followed
Principles of method if other than guideline:
The EU RAR summarises the results of a number of relevant studies
GLP compliance:
no
Analytical monitoring:
not specified
Details on sampling:
No details of sampling given in review.
Vehicle:
no
Details on preparation and application of test substrate:
No details on preparation and application of test substance given in the review.
Test organisms (inoculum):
soil
Total exposure duration:
63 d
Test temperature:
Not stated
Moisture:
Not stated.
Details on test conditions:
No further details given in review
Nominal and measured concentrations:
not stated
Reference substance (positive control):
no
Duration:
24 d
Dose descriptor:
NOEC
Effect conc.:
3 000 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Dehydrogenase inhibition
Remarks on result:
other: sodium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
340 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: NH4-minerilisation
Remarks on result:
other: potassium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
106 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: NO3-mineralisation
Remarks on result:
other: potassium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
1 060 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: P-mineralisation
Remarks on result:
other: potassium fluoride
Details on results:
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
Not applicable

The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive in the micro-ecosystem test.

Validity criteria fulfilled:
not applicable
Conclusions:
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
Executive summary:

The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.

Endpoint:
toxicity to soil microorganisms
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, hydrogen and titanium ions upon dissolution in the environment. However, hydrogen and titanium ions do not remain as such in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017).

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
sodium fluoride (CAS 7681-49-4)
potassium fluoride (CAS 7789-23-3)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)

3. ANALOGUE APPROACH JUSTIFICATION
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the lowest available NOEC of 106 mg F/kg for the long-term toxicity (63 days) of potassium fluoride to NO3-mineralisation (nitrification) is read-across to dihydrogen hexafluorotitanate resulting in a NOEC of 152.4 mg/kg.

4. DATA MATRIX
see attached read-across statement in section 13.2
Reason / purpose for cross-reference:
read-across source
Duration:
24 d
Dose descriptor:
NOEC
Effect conc.:
3 000 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Dehydrogenase inhibition
Remarks on result:
other: sodium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
340 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: NH4-minerilisation
Remarks on result:
other: potassium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
106 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: NO3-mineralisation
Remarks on result:
other: potassium fluoride
Duration:
63 d
Dose descriptor:
NOEC
Effect conc.:
1 060 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: P-mineralisation
Remarks on result:
other: potassium fluoride
Details on results:
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
Not applicable

The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive in the micro-ecosystem test.

Validity criteria fulfilled:
not applicable
Conclusions:
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
Executive summary:

The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.

Description of key information

Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the lowest available NOEC of 106 mg F/kg for the long-term toxicity (63 days) of potassium fluoride to NO3-mineralisation (nitrification) is read-across to dihydrogen hexafluorotitanate resulting in a NOEC of 249.9 mg/kg (based upon a molecular weight conversion (and correction to max. purity).

Key value for chemical safety assessment

Long-term EC10 or NOEC for soil microorganisms:
249.9 mg/kg soil dw

Additional information

Dihydrogen hexafluorotitanate


Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of soil microbial toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below).


 


Fluorides


The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.