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EC number: 223-496-2 | CAS number: 3923-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 06.09.2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to attached QMRF and QPRF Documents.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Principles of method if other than guideline:
- Calculation of Long-Term toxicity in aquatic invertebrates. Software used: ECOSAR 2.2 for chemical class "Substituted Ureas"
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CN1C(O)C(O)N(C)C1=O
- Analytical monitoring:
- not required
- Test organisms (species):
- Daphnia sp.
- Water media type:
- freshwater
- Remarks on exposure duration:
- chronic exposure (duration not specified)
- Key result
- Dose descriptor:
- other: ChV
- Effect conc.:
- 37 400 mg/L
- Remarks on result:
- other: ChV (chronic value, QSAR); The substance is within the applicability domain of the model. ECOSAR class "Substituted Ureas".
- Validity criteria fulfilled:
- yes
- Conclusions:
- Using ECOSAR v2.2 the long-term toxicity ChV value for aquatic invertebrates was calculated to be 37400 mg/L. The substance is within the applicability domain of the model.
- Executive summary:
The long-term toxicity in aquatic invertebrates was calculated using ECOSAR v2.2 from US Environmental Protection Agency. The ChV (chronic value) was estimated to be 37400 mg/L.
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QMRF and QPRF files were developed and attached to this study record.
Description of the prediction Model
The prediction model was descriped using the harmonised template for summarising and reporting key information on (Q)SAR models. For more details please refer to the attached QSAR Model Reporting Format (QMRF) file.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
Reference
Description of key information
Using ECOSAR v2.2 the long-term toxicity ChV value for aquatic invertebrates was calculated to be 37400 mg/L. The substance is within the applicability domain of the model.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 37 400 mg/L
Additional information
Using ECOSAR v2.2 the long-term toxicity ChV value for aquatic invertebrates was calculated to be 37400 mg/L. The substance is within the applicability domain of the model. No effects in the acute aquatic studies were observed and in combination with the QSAR prediction, it can be concluded that the test item doesn't pose any risk to the aquatic environment and the performance of a new invertebrate test is considered scientifically not justified.
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