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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

There are no toxicokinetic studies available with 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one. The following toxicokinetic assessment is based on the available information on physico-chemical parameters and results from other (eco)toxicity studies with 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one:


4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one is manufactured and handled in aqueous solution with an experimentally determined vapour pressure of 23,9 hPa at 20 °C (Note: The vapour pressure of water is about 23 hPa at 20°C), whereas the pure substance is a white hard paste solid liquid with a negligible vapour pressure of 0.000000153 hPa at 20°C (calculated).

4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one has a molecular weight of 146 g/mol, is miscible in water at any ratio, and has a low log Pow of -3.93 at 25°C (calculated).


An acute oral toxicity studies in rats provided no evidence for systemic availability of 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one by the oral route (no mortality, clinical symptoms or gross pathological abnormalities observed.

In an acute dermal toxicity study in rabbits with 24-hour exposure to undiluted 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one under an occlusive coverage no mortality or signs of systemic toxicity were observed. Upon removal of the binders from the animals, the exposed area and binder appeared dry with no sample apparent on any of the animals. This observation provides evidence for dermal absorption of the substance.

The negative result of an in vitro genotoxicity study in bacteria (Ames test) with and without metabolic activation indicates that no reactive metabolites have been formed after incubation of the substance with rat liver S9 mix.

Based on the log Pow of -3.93 accumulation of the substance in organisms is not to be expected.