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Short-term toxicity to fish

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Description of key information

The substance is with high probability acutely not harmful to fish.

Key value for chemical safety assessment

Additional information

The results of a static exposure test conducted according to DIN 38412 part 15, using Leuciscus idus as test species (BASF AG, 1987), indicate that the test substance is with high probability not acutely harmful to fish. Based on nominal test item concentrations the 96-h LC50 was determined to be in a range of 215 - 464 mg/L. Neutralization of the highest test concentration of 1000 mg/L completely abolished mortality. Therefore, the observed adverse effects may be due to pH.


The study was conducted without analytical monitoring. However, the stability of MIPA in the test medium is considered to be stable due to the high water solubility (miscible at any ratio; see IUCLID chapter 4.8), the low vapour pressure (63 Pa at 25 °C; see IUCLID chapter 4.6) and the low Henry's law constant (HLC: 4.95E-5 Pa*m3/mol; calculated; HENRYWIN v3.20, EPISuite v4.11) of the substance.


Additional studies using non-neutralized test solutions support these findings. Bridie et al. (1979), determined a 96 -h LC50 of goldfish exposed to non-neutralized samples as 210 mg/L whereas neutralization of the test solutions resulted in a 96-h LC50 of > 5000 mg/L. In a flow-through test Brooke and co-workers (1984) determined a 96 -h LC50 of 2520 mg/L for Pimephales promelas, when exposed to the test item using neutralized stock solutions.


In conclusion, substance is with high probability acutely not harmful to fish.