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EC number: 201-162-7 | CAS number: 78-96-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- no further details
- GLP compliance:
- no
- Test type:
- other: acute method, no further details
- Limit test:
- no
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 1-aminopropan-2-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 2 weeks
- Doses:
- 630 - 5000 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 851 mg/kg bw
- Mortality:
- Mortality was observed in animals but no detailed information are given.
- Clinical signs:
- other: Marked redness, moderate swelling, and marked necrosis of the skin were observed. At all doses, rabbits were lethargic. At doses of 630 and 1300 mg/kg, anorexia was observed, and at a dose of 1300 mg/kg, diarrhea was observed.
- Gross pathology:
- At necropsy at the end of a 2-week observation period, no treatment-related changes were noted.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the LD50 value and in combination with the observed clinical effects in animal, the substance is suggested to be of low dermal acute toxicity.
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