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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
no further details
GLP compliance:
no
Test type:
other: acute method, no further details
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-aminopropan-2-ol
EC Number:
201-162-7
EC Name:
1-aminopropan-2-ol
Cas Number:
78-96-6
Molecular formula:
C3H9NO
IUPAC Name:
1-aminopropan-2-ol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
2 weeks
Doses:
630 - 5000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 851 mg/kg bw
Mortality:
Mortality was observed in animals but no detailed information are given.
Clinical signs:
other: Marked redness, moderate swelling, and marked necrosis of the skin were observed. At all doses, rabbits were lethargic. At doses of 630 and 1300 mg/kg, anorexia was observed, and at a dose of 1300 mg/kg, diarrhea was observed.
Gross pathology:
At necropsy at the end of a 2-week observation period, no treatment-related changes were noted.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Based on the LD50 value and in combination with the observed clinical effects in animal, the substance is suggested to be of low dermal acute toxicity.