Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-162-7 | CAS number: 78-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemical Mutagenesis Testing in Drosophila. IX . Results of 50 Coded Compounds Tested for the National Toxicology Program
- Author:
- Foureman P, Mason JM, Valencia R, Zimmering S
- Year:
- 1 994
- Bibliographic source:
- Environmental and Molecular Mutagenesis 23(1):51-63
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 477 (Genetic Toxicology: Sex-linked Recessive Lethal Test in Drosophila melanogaster)
- Version / remarks:
- The guideline is not specified but given the scientific description of the study, performance similar to OECD 477 is suggested.
- Principles of method if other than guideline:
- Method: Woodruff, RC et al., Env. Mutagen., 6, 189-202.
Adult Canton-S males were subjected to a 3 day feeding exposure. They were mated to Basc females using a 2 to 3 day brooding pattern for a total of
three broods spanning 7 days. If the feeding sex-linked recessive lethal (SLRL) test was negative, an injection exposure was performed. As in the feeding exposure, a 2 to 3 day brooding pattern for three broods was used. - GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 1-aminopropan-2-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Purity: 96.4 %
- Supplier: Aldrich (3803 LE)
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton S
- Sex:
- male
Administration / exposure
- Route of administration:
- other: In feed. If the results of the feeding SLRL test were negative, an injection exposure was performed.
- Vehicle:
- Water
- Duration of treatment / exposure:
- feeding study: 3 days; If the results of the feeding SLRL test were negative, a single injection exposure was performed.
- Frequency of treatment:
- continuously in feed
Doses / concentrationsopen allclose all
- Dose / conc.:
- 24 250 ppm
- Remarks:
- feeding study
- Dose / conc.:
- 1 940 ppm
- Remarks:
- injection
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
Examinations
- Evaluation criteria:
- A minimum of approximately 5,000 chromosomes were scored in each of the treated and concurrent control groups, unless the mutant frequency exceeded 1%. Clusters were identified using the Poisson distribution (Owen, 1962) and were removed before analysis.
- Statistics:
- The statistical evaluation of a SLRL test included a comparison with the concurrent solvent control using the normal approximation to the binomial distribution, as presented by Margolin et al. (1983), as well as a comparison with the historical control as described by Mason et al. (1992). In order to be considered mutagenic, the mutant frequency in the treated sample must exceed 0.15% with a P value of less than 0.05, or the treated frequency must exceed 0.1% with a P value of less than 0.01. If the treated frequency was between 0.1% and 0.15% and the P value was between 0.1 and 0.01; or if the treated frequency was higher than 0.15%, and the P value was between 0.1 and 0.05 the assay was considered equivocal. All other assays were considered negative.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Table 1: Results of the drosophila testing in Mono-isopropanolamin.
Dose (ppm) |
ROA |
Percent mortality |
Percent sterility |
Lethals |
Tests |
Total lethals |
Total tests |
Percent lethals |
||||
|
|
|
|
Br 1 |
Br 2 |
Br 3 |
Br 1 |
Br 2 |
Br 3 |
|
|
|
24,000 |
feeding |
5 |
17 |
1 |
0 |
2 |
2,658 |
1,421 |
847 |
3 |
4,926 |
0.06 |
0 |
|
|
|
1 |
0 |
1 |
2,875 |
2,748 |
2,414 |
2 |
8,037 |
0.02 |
1,900 |
injection |
14 |
8 |
2 |
2 |
2 |
1,911 |
1,675 |
1,562 |
6 |
5,148 |
0.12 |
0 |
|
|
|
0 |
2 |
0 |
1,739 |
1,493 |
1,079 |
2 |
4,311 |
0.05 |
One cluster of 3 in the injection control and one of 4 in the treated feeding experiment
Applicant's summary and conclusion
- Conclusions:
- Under the conditions tested the test substance was not mutagenic in a Drosophila SLRL assay.
Thus, MIPA is not considered to be genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.