Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

genetic toxicity in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study does not meet the current guideline and was not performed under GLP.

Data source

Reference Type:

Materials and methods

Test material

Results and discussion

Applicant's summary and conclusion

Executive summary:

In examinations of the bone-marrow as well as germ cells of 2 strains of mice (ICR, CFLP) was found that NaSCN applied at a dose of 64 mg/kg daily on 3 consecutive days significantly decreases the frequency of the chromosome aberrations evoked by cyclophosphamide, from 68% to 52% in the bone-marrow cells ( α <1%) and from 25% to 16% in the germ cells (α < 5%). With regard to the medical and biological importance of the thiocyanates it seems promosing to subject these findings to a deeper treatment.