Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 208-754-4 | CAS number: 540-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study did not follow OECD guidelines and was not performed under GLP. Only reports on the effect of KSCN on nutrient transport to the brain in pups. Only one dose level.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Details on test material:
- KSCN
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Details on mating procedure:
- females were mated with control males
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 8 weeks before and during gestation and lactation
- Frequency of treatment:
- daily via food
- Details on study schedule:
- - F1 parental animals not mated until ± 10 weeks after selected from the F1 litters.
- Selection of parents from F1 generation when pups were unknonw days of age.
- Age at mating of the mated animals in the study: ± 10-12 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
± 25 mg/rat/day
Basis:
nominal in diet
- No. of animals per sex per dose:
- unknown
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Continuous feeding of KSCN to females through 2 generations at a level of 25 mg/rat per day, seems to have an adverse effect on the nutrient transport across the blood brain barrier in the F2 generation. However due to the limitations of the study a firm conclusion cannot be drawn.
- Executive summary:
Populations living in goitre endemic areas consume foods rich in a variety of goitrogens of different potencies and some are severely hypothyroid. Recently we observed in Wistar:NIN rats that chronic feeding of KSCN to dams produced only a moderate hypothyroidism and decreased the transport of 2 -deoxy-D-glucose(2 -DG) across the blood-brain barrier (BBB) in the offspring. The present studies were conducted to assess whether severe hypothyroidism would have greater effect on BBB nutrient transport. It has now been observed that weaning the pups of KSCN fed dams on to KSCN diet for four weeks had no further effect either on their thyroid status or the BBB 2 -DG transport. However, feeding KSCN to rats through two generations produced somewhat severe hypothyroidism in F1 pups than that in F0 pups. Interestingly, unlike in F0 pups, the BBB transport of all the three nutrients tested (2 -DG, Leu and Tyr) was significantly decreased in F1 pups, albeit to a small extent (10 -15%). On the other hand the potent goitrogen, methyl mercaptoimidazole (MMI) even on short term feeding to pregnant dams produced very severe hypothyroidism in the offspring (Serum T4:0.55 ± 0.099 µg/dl vs 4.96 ± 0.85 in controls). Surprisingly, the BBB transport of 2 -DG, Leu, Tyr and also
sucrose, the background marker, was significantly increased in these pups (20 -30%). The diverse effects of goitrogen induced moderate and severe hypothyroidism observed here on the BBB nutrient transport probably suggest different mechanisms for iodine deffciency disorders of different aetiologies and hence the need for discrete approaches for their management.
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