Registration Dossier
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EC number: 204-699-5 | CAS number: 124-41-4
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- The QSAR (Quantitativ Structure Activity Relationship)-method estimates the Henry´s Law Constant of organic chemicals using an atom/fragment contribution method developed at SRC (Syracuse Research Corporation)
- GLP compliance:
- no
- H:
- 0.304 Pa m³/mol
- Temp.:
- 25 °C
Reference
Original value reported: 0.000003 atm mE3/mol at 25°C
Description of key information
Sodium methanolate has a low potential for volatilisation from the water phase.
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 0.304
- at the temperature of:
- 25 °C
Additional information
In water, sodium methanolate rapidly hydrolyses forming methanol and sodium hydroxide (OECD, 2002). The Henry's Law constant for sodium methanolate was calculated via QSAR and resulted in a value of 0.304 Pa m³/mol (study director, 2005b) (based on methanol as surrogate) indicating a low potential for volatilisation. However, due to the rapid hydrolysis sodium methanolate is not expected to be present in teh environment as such.
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