Registration Dossier
Registration Dossier
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EC number: 204-699-5 | CAS number: 124-41-4
Endpoint summary
Administrative data
Description of key information
Data waiving due to skin corrosive properties of the substance.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
A study on the skin sensitisation potential does not need to be conducted according to Annex VII, Section 8.3, Column 2 of the REACH regulation, as sodium methanolate is classified as corrosive to the skin. However, the available data on the skin sensitisation potential of the hydrolysis products sodium hydroxide (CAS No. 1310-73-2) and methanol (CAS No. 67-56-1) were taken into account for classification and labelling purposes (please refer to the endpoint summaries of methanol and sodium hydroxide for more details). According to the OECD SIDS of the methanolates (OECD, 2006) it can be concluded from the data of the hydrolysis products that sodium methanolate is not expected to have a skin sensitisation potential.
References not included in IUCLID:
OECD SIDS Initial Assessment Report for SIAM 22 (2006): Category of Methanolates: Sodium Methanolate, Potassium Methanolate (CAS No: Sodium Methanolate: 124-41-4; Potassium Methanolate: 865-33-8).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
There are no data available on the skin sensitisation potential of sodium methanolate. Sodium methanolate is classified as corrosive to the skin according to Annex VI of the CLP regulation (EC 1272/2008), therefore no additional data on the skin sensitisation potential of sodium methanolate is necessary according to Annex VII, Section 8.3, Column 2 of the REACH regulation. For classification and labelling purposes, the available data of the hydrolysis products (sodium hydroxide and methanol) were taken into account. The available data on the hydrolysis products are conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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