Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A GLP study according to OECD guideline 404 and two GLP-studies according to OECD guideline 405 are available for phenoxypropanol.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin: no irritation was observed in any of the test animals after dermal application of phenoxpropanol. The mean scores for both erythema and edema were 0 at 24, 48 and 72 hours.

Eye: in both studies conducted with phenoxypropanol reversible irritation was observed after application to rabbit eyes.

Effects on eye irritation: irritating

Justification for classification or non-classification

Skin irritation: according to EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC) and GHS/CLP the mean value for erythema and edema scores was 0 for all animals at any time. Hence, phenoxypropanol is not classified as skin irritant.

Eye irritation: according to the annex VI of the council directive 67/548 EEC (amended by directive 83/467 EEC) and GHS/CLP the maximum average scores of the 3 animals for cornea opacity, iris lesions, conjunctivae and chemosis were 1.0, 0.7, 3.0 and 1.3, respectively at 24, 48 and 72 hours. All effects were reversible within 14 days. According to EU criteria phenoxypropanol is classified for eye irritation.