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EC number: 212-222-7 | CAS number: 770-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted in compliance with GLP regulations
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1-phenoxypropan-2-ol
- EC Number:
- 212-222-7
- EC Name:
- 1-phenoxypropan-2-ol
- Cas Number:
- 770-35-4
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-phenoxypropan-2-ol
- Reference substance name:
- 1-phenylpropan-2-ol
- EC Number:
- 211-821-0
- EC Name:
- 1-phenylpropan-2-ol
- Cas Number:
- 698-87-3
- IUPAC Name:
- 1-phenylpropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Protectol PP (#96/344)
- Physical state: liquid / colorless
- Analytical purity: mixture (86/14.9%)
- Composition of test material, percentage of components: 84.8% 1-phenoxy-propan-2-ol and 14.7% 2-phenoxy-propan-1-ol
- Stability under test conditions: verified by reanalysis
- Storage condition of test material: at room temperature
Constituent 1
Constituent 2
Method
- Target gene:
- not applicable
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537
- Details on mammalian cell type (if applicable):
- - Type and identity of media: no data
- Properly maintained: no data
- Periodically checked for Mycoplasma contamination: no data
- Periodically checked for karyotype stability: no data
- Periodically "cleansed" against high spontaneous background: no data - Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix (Arochlor induced rat liver)
- Test concentrations with justification for top dose:
- standard plate test : 0, 20, 100, 500, 2500 & 5000 μg/plate +/- S9 mix from Arochlor-induced rat liver
preincubation test : 0, 20, 100, 500, 2500 & 5000 μg/plate +/- S9 up to 5000 micrograms per plate - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Justification for choice of solvent/vehicle: stability of the test substance in DMSO and in water was assured analytically
Controls
- Untreated negative controls:
- yes
- Remarks:
- sterility control
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-Aminoanthracene (2-AA), N-methyl-N’-nitro-N-nitroso guanidine (MNNG), 4-nitro-o-phenylenediamine (NOPD), 9-amino acridine (AAC), N-ethyl-N’-nitro-N-nitroso guanidine (ENNG)
- Details on test system and experimental conditions:
- FIRST EXPERIMENT - METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Preincubation period: not applicable
- Exposure duration: 48 - 72 hours
- Expression time (cells in growth medium): 48 - 72 hours
DETERMINATION OF CYTOTOXICITY
- Method: cloning efficiency
SECOND EXPERIMENT - METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min
- Exposure duration: 48 - 72 hours
- Expression time (cells in growth medium): 48 - 72 hours
DETERMINATION OF CYTOTOXICITY
- Method: cloning efficiencyes - Evaluation criteria:
- In general, a substance to be characterized as positive in the bacterial tests has to fulfill the following requirements: doubling of the spontaneous mutation rate (control), dose-response relationship and reproducibility of the results.
- Statistics:
- standard statistical methods
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Additional information on results:
- no data
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Solubility in DMSO and stability of test substance in DMSO and water was analytically checked. No precipitation of test substance was observed. No increase of revertants (his+ revertants) was seen with test substance with any of the tester strains, neither with nor without S9, neither in the standard plate test nor in the preincubation test.
The results of negative and positive controls indicated that the tests were valid. Occasionally a slight decrease in the number of his+ revertants was observed, indicating weak bacterial toxicity.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Under the conditions of the study, Propylene glycol phenyl ether was not mutagenic in the Ames test. - Executive summary:
In this AMES test conducted according to the OECD TG 471 and TG 472 and EU Method B.13/14, Salmonella typhimurium strains (TA98, TA 100, TA 1535 and TA 1537) were exposed to Propylene glycol phenyl ether following the standard plate test and the preincubation test in the presence and absence of S9 mix from Arochlor-induced rat liver) at concentrations ranging from 20, 100, 500, 2500 and 5000 μg/plate. Untreated controls were also evaluated in the study. Also, 2-Aminoanthracene (2-AA), N-methyl-N’-nitro-N-nitroso guanidine (MNNG), 4-nitro-o-phenylenediamine (NOPD), 9-amino acridine (AAC), N-ethyl-N’-nitro-N-nitroso guanidine (ENNG) were used as positive controls.
The results indicated that there was no increase in number of his+ and trp+ revertants in either standard plate or preincubation test. Hence, under the conditions of the study, Propylene glycol phenyl ether was not considered mutagenic in the Ames test.
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