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EC number: 227-231-1 | CAS number: 5726-19-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 17, 2012 - June 1, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.44 g/L
- Temp.:
- 20 °C
- pH:
- 5.6
- Details on results:
- Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was 0.44 g/l at (20 ± 0.1)ºC.
- Conclusions:
- Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was 0.44 g/l at (20±0.1)ºC.
- Executive summary:
Determination of water solubility, using shake flask method, was carried out according to the method EEC A.6. (OECD 105) (flask method). The substance was dissolved in water at a temperature above the test temperature (30 ºC). When saturation was achieved, the mixture was cooled and kept at the test temperature (20 ºC). Subsequently, the mass concentration of the substance in the aqueous solution, which must not contain any undissolved particles, was determined by a suitable HPLC method. Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20±0.1)ºC.
Reference
Results of 2-methylcyclohexyl acetate solubility at (20±0.1)ºC in water at pH = 5.6:
Mixing time [days] |
1 |
2 |
3 |
|
1 flask |
Concentration of 2-methylcyclohexyl acetate, [g/l] |
0.39 |
0.46 |
0.45 |
pH |
5.31 |
5.20 |
5.33 |
|
2 flask |
Concentration of 2-methylcyclohexyl acetate, [g/l] |
0.41 |
0.47 |
0.45 |
pH |
5.29 |
5.26 |
5.35 |
|
Average concentration of 2-methylcyclohexyl acetate, [g/l] |
0.40 |
0.47 |
0.45 |
|
The calculated average solubility, [g/l] |
0.44 |
|||
Description of key information
Key study: Test method EEC A.6 and OECD 105. GLP study. The solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20 ± 0.1) ºC.
Key value for chemical safety assessment
- Water solubility:
- 0.44 g/L
- at the temperature of:
- 20 °C
Additional information
Key study: Determination of water solubility, using shake flask method, was carried out according to the method EEC A.6. (OECD 105) (flask method). The solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20 ± 0.1)ºC.
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