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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 17, 2012 - June 1, 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.44 g/L
Temp.:
20 °C
pH:
5.6
Details on results:
Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was 0.44 g/l at (20 ± 0.1)ºC.

Results of 2-methylcyclohexyl acetate solubility at (20±0.1)ºC in water at pH = 5.6:

Mixing time [days]

1

2

3

1 flask

Concentration of 2-methylcyclohexyl acetate, [g/l]

0.39

0.46

0.45

pH

5.31

5.20

5.33

2 flask

Concentration of 2-methylcyclohexyl acetate, [g/l]

0.41

0.47

0.45

pH

5.29

5.26

5.35

Average concentration of 2-methylcyclohexyl acetate, [g/l]

0.40

0.47

0.45

The calculated average solubility, [g/l]

0.44

Conclusions:
Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was 0.44 g/l at (20±0.1)ºC.
Executive summary:

Determination of water solubility, using shake flask method, was carried out according to the method EEC A.6. (OECD 105) (flask method). The substance was dissolved in water at a temperature above the test temperature (30 ºC). When saturation was achieved, the mixture was cooled and kept at the test temperature (20 ºC). Subsequently, the mass concentration of the substance in the aqueous solution, which must not contain any undissolved particles, was determined by a suitable HPLC method. Solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20±0.1)ºC.

Description of key information

Key study: Test method EEC A.6 and OECD 105. GLP study. The solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20 ± 0.1) ºC.

Key value for chemical safety assessment

Water solubility:
0.44 g/L
at the temperature of:
20 °C

Additional information

Key study: Determination of water solubility, using shake flask method, was carried out according to the method EEC A.6. (OECD 105) (flask method). The solubility of the 2-methylcyclohexyl acetate in distilled water at pH 5.6 was determined to be 0.44 g/l at (20 ± 0.1)ºC.

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