Registration Dossier
Registration Dossier
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EC number: 225-218-5 | CAS number: 4724-48-5
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study planned
- Justification for type of information:
- NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out: octylphosphonic acid
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION
- Available GLP studies: none
- Available non-GLP studies: none
- Historical human/control data: not appicable
- (Q)SAR: none
- In vitro methods: none
- Weight of evidence: no
- Grouping and read-across: not available
- Substance-tailored exposure driven testing [if applicable]: the long term toxicity study on aquatic invertebrates it is a requirement of Annex IX and should be done in order to evaluate the PNEC.
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- as per Specific Adaptation of Annex IX "Long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The choice of the appropriate test(s) depends on the results of the chemical safety assessment." Therefore, the long term toxicity testing is mandatory in order to furtherly investigate the effects on aquatic organisms.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed: OECD Guideline 211 methodology.
Data source
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
Test material
- Reference substance name:
- Octylphosphonic acid
- EC Number:
- 225-218-5
- EC Name:
- Octylphosphonic acid
- Cas Number:
- 4724-48-5
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- octylphosphonic acid
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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