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EC number: 292-550-5 | CAS number: 90640-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.26 µg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.6 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.026 µg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 550 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 3.76 mg/kg sediment dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.376 mg/kg sediment dw
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 10 mg/kg soil dw
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
The ECHA Committee for Risk Assessment decided on the Harmonized Classification & labeling according 2ndATP of CLP Regulation (2011/286/EU) and DSD (67/548/EEC) for the five Primary alkyl amines of the Category Approach (ECHA, 2011). This CLH is also adopted for the Dodecyl amine and C12-14(even numbered) alkyl amines being part of the extended Category approach.
The rationale for the Harmonized Classification and Labeling is given in the Annex 1 Background documents of the Committee for Risk Assessment (RAC):
- For Amines, tallow alkyl see ECHA/RAC/CLH-O-0000002199-69-01/A1 (DocLinkhttp://echa.europa.eu/documents/10162/13626/rac_annex1_bd_amines_tallow_alkyl+5_en.pdf)
- For Amines, coco alkyl see ECHA/RAC/CLH-O-0000002195-77-01/A1 (DocLinkhttp://echa.europa.eu/documents/10162/13626/rac_annex1_bd_amines_coco_alkyl+5_en.pdf)
- For Amnes, hydrogenated tallow alkyl see ECHA/RAC/CLH-O-0000002198-71-01/F (DocLinkhttp://echa.europa.eu/documents/10162/1e7eed4f-1662-43c3-b62c-ec60cce7431b)
- For Octadecylamine see ECHA/RAC/CLH-O-0000002196-75-01/F
- (DocLinkhttp://echa.europa.eu/documents/10162/e7e2c472-0902-4ee2-a7a2-f2803204cab7)
- For (Z)-octadec-9-enylamine see ECHA/RAC/CLH-O-0000002197-73-01/F (DocLinkhttp://echa.europa.eu/documents/10162/bd40638b-9be4-46a4-a074-cab59a04758e)
Harmonized Classification according 2ndATP of CLP (2011/286/EU)
Acute (short-term) aquatic hazard
The lowest reliable short-term aquatic toxicity result for this category is a 48-h EC50 of 0.011 mg/L forDaphnia magna based on nominal concentrations for (Z)-octadec-9-enylamine (due to the lack of recovery rates it is expected the real EC50 to be lower). Therefore,Primary alkyl amines of the (extended) Category Approach are classifiable as Aquatic Acute 1 (H400). Since this toxicity value is in the range 0.01- 0.1 mg/L, the M-factor (Acute) applied would be 10.
Chronic (long-term) aquatic hazard
Two different approaches are included, both justifying the same result:
Two long-term results are available (for invertebrates and algae), both of which give NOECs of
0.01 mg/l or lower. Therefore, the substance is classifiable as Aquatic Chronic 1 (H410) based on toxicity information. The rapid degradability of the substance affects the M-factor, but since it is unclear how much lower the true NOECs might be (the behaviour of the substance and
experimental designs mean that the true exposure concentrations are unknown) it not considered
relevant to set an M-factor based on these data. As fully reliable chronic toxicity data are not available for any of the three trophic levels, the surrogate approach can be applied, based on acute effects and fate properties. The lowest acute L(E)C50s for all three trophic groups are in the range 0.01 - 0.1 mg/l, and the realistic worst case BCF is > 500 for fish, based on the study for hexadecylamine as representative substance (and the estimated log Kow > 4). Consequently,Primary alkyl amines of the (extended) Category Approachfulfil the criteria for classification as Aquatic Chronic 1 (H410). The M-factor (chronic) is 10, according to the surrogate approach, based on the acute toxicity data.
Classification according to the DSD criteria
The classification as N; R50/53 (Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment) is adequate, because although the amines in question are readily biodegradable, they have BCFs for fish above 100, and a 48-h EC50 of 0.011 mg/L forDaphnia magna.The following specific concentration limits should be applied:
Classification Concentration
N; R50/53 C≥2.5%
N; R51/53 0.25%≤C < 2.5%
R52/53 0.025%≤C < 0.25%
Where C is the concentration of the amine.
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