Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In a GLP compliant OECD TG 404 study, 0.5 ml hydrogenated tallow alkylamines (Lilamin AC-HBG-P) were semi-occlusively applied to the shaved skin of three New Zealand White rabbits for 4 hours. Well-defined erythema and oedema were observed up to day 11 after removal of the patches. All signs of irritation were reversible.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

There are no human data on acute toxicity for hydrogenated tallow alkylamines nor for any of the other primary alkylamines considered a chemical category with respect to chemical safety assessment. In animals, data from all alkylamines demonstrated a significant dermal irritative potential of this chemical category. C12 -18 -(even numbered)-alkylamines as well as tallow alkylamines and octadecenylamines were shown to be corrosive to rabbit skin, and, in consequence, not tested in rabbit eye. Hydrogenated tallow alkylamines and octadecylamines induced less severe effects in skin but caused severe eye irritation up to irreversible damage in the rabbit eye. For C12 -18 -(even numbered)-alkylamines, rat inhalation studies indicated irritative properties on the respiratory tract.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: highly irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Hydrogenated tallow alkylamines fulfill the requirements for classification as Irritant with the designation R38 - irritating to skin and R41 - risk of serious damage to eyes. Based on the dermal corrosive properties no testing for eye irritation was performed.