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EC number: 272-810-4 | CAS number: 68915-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
COP acid and the read across ingredient, adipic acid, have very low acute toxicity. The oral and dermal LD50 in rats are > 5000 mg/kg bw. In an acute inhalation test neither mortality nor symptoms were observed during and after 4 hour exposure to 7700 mg/m3 of adipic acid.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 560 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 7 700 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 7 940 mg/kg bw
Additional information
Read Across (Adipic Acid):
Hazards identified by OECD/ICCA high production volume chemicals program in 2004:
Oral toxicity:
"In rats, an LD50 value of 5560 mg/kg bw was established in a study similar to OECD TG 401 performed with single doses up to 10 000 mg/kg bw of adipic acid (99.8 %) administered as 50 % suspension in carboxymethyl cellulose vehicle. Mortality was seen during the first 48 hours. Lethal doses caused acute dilatation of the heart and acute congestive hyperaemia, ulceration of glandular stomach (bleeding-corrosive gastritis), pale liver, intestinal atony and reddening of intestinal mucosa. Animals that survived to termination at 14 days showed no gross pathological changes. The doses used in this test were in excess of the currently accepted limit dose (BASF 1978).
No signs of toxicity were observed following administration of a single dose of 5000 mg/kg bw of adipic acid (suspended in saline) to ten male rats (Litton Bionetics Inc. 1974).
In mice, an LD50 value of 1900 mg/kg bw was established after the administration of adipic acid (6 % solution in 0.5 % methyl cellulose) to groups of 13 male animals. Autopsy of animals that died during the experiment showed distention of the stomach and irritation and hemorrhage of the intestines as well as spastic contraction of the caecum. Initial mortality developed overnight and deaths continued throughout the first week, survivors appeared normal (Horn et al., 1957)."
Inhalation toxicity:
"In a study similar to OECD TG 403, neither mortality, toxic symptoms nor macroscopic pathological changes were observed in 20 rats exposed for 4 hours (nose only) to the maximal attainable concentration of 7700 mg/m3 of adipic acid (99.8 %) dust. 50 % of the particles had a MMAD below 3.5 µm."
Dermal toxicity:
"No lethality was reported in rabbits following occlusive dermal administration of 5010 (n = 1) and 7940 mg/kg bw (n = 2) of 40 % adipic acid in corn oil for 24 hours. Animals showed reduced appetite and activity and the viscera were normal at necropsy after 14 days observation. Due to the low animal number the study is of limited reliability, however the result is consistent with the low acute oral toxicity."
Acute toxicity other routes:
Limited studies are cited in IUCLID database prepared for the OECD/ICCA high production volume chemicals program in 2004. LD50 values are reported between 275 and 600 mg/kg bw after i.p. injection in mice and a LD0 of 2450 mg/kg bw was reported after i.v. injection in rabbits.
Human information:
Hazards identified by OECD/ICCA high production volume chemicals program in 2004:
"There are no acute toxicity studies in humans reported. No overt toxic symptoms were reported after oral administration of up to 7 g of adipic acid per day, for 10 days to one volunteer (100 mg/kg bw. per day) to investigate compound excretion (Weitzel, 1942 and 1947)."
Updated relevant information:
None
Overall:
Adipic acid is of very low acute toxicity. The oral LD50 in rats in a study similar to OECD TG 401 is approximately 5560 mg/kg bw. Clinical signs at lethal doses included acute dilatation of the heart and acute congestive hyperaemia, ulceration of glandular stomach (bleeding-corrosive gastritis), intestinal atony, pale liver and reddening of intestinal mucosa. The LD50 for mice was reported to be 1900 mg/kg bw. In an inhalation test similar to OECD TG 403 in rats neither mortality nor symptoms were observed during and after 4 hour exposure to 7700 mg/m3 of adipic acid. Reduced appetite and activity were the only effects reported following occlusive dermal administration of 7940 mg/kg bw of adipic acid to 2 rabbits for 24 hours.
Justification for classification or non-classification
Adipic acid is of very low acute toxicity. No classification is required according to the EU classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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