Registration Dossier
Registration Dossier
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EC number: 272-810-4 | CAS number: 68915-38-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: verry limited information
Data source
Reference
- Reference Type:
- publication
- Title:
- Clinical and experimental characteristics of the toxic action of adipic acid and bases for setting its TLV in workplace air.
- Author:
- Krapotkina MA, Garkavenko OS, Abramova EM, Galickaja VA, Kublanova PS, Bereznjak IV, Promyslova AD
- Year:
- 1 981
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 5, 46-47 (Russian).
Materials and methods
- Principles of method if other than guideline:
- End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "Overall remarks".
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- Hexanedioic Acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: no data
- Duration of treatment / exposure:
- 1.5 to 4 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
13 and 129 mg/m3 (4 months exposure), 460 mg/m3 (1.5 months exposure)
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "Overall remarks".
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
