Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-810-4 | CAS number: 68915-38-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limited reporting
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexane, oxidized, aquous extract
- IUPAC Name:
- Cyclohexane, oxidized, aquous extract
- Reference substance name:
- Cyclohexane, oxidized, aq. ext.
- EC Number:
- 272-810-4
- EC Name:
- Cyclohexane, oxidized, aq. ext.
- Cas Number:
- 68915-38-8
- Molecular formula:
- not available
- IUPAC Name:
- Cyclohexane, oxidized, aq. ext.
- Details on test material:
- - Name of test material (as cited in study report): Dicarbonicacid-solution, "Abstreifsäure"
- Product No.: 62252
- substance No.: 87/220
- Approx. solid content: 45%, water content: 55%
- density: 1.06g/ml (45°C)
- vapour pressure 23mbar
- 5% solution pH 2.4
- Physical state: Yellow liquid
- Composition of test material, percentage of components:
16.7% Adipinic acid (CAS-Nr. 124-04-9)
13.2% 6-Hydroxycaproic acid (CAS-Nr.1191-25-9)
2.1% Glutaric acid (CAS-Nr. 110-94-1 )
0.8% succinic acid (CAS-Nr. 13392-69-3)
0.2% valeric acid
(CAS-Nr. 109-52-4)
0.2% butanoic acid
(CAS-Nr. 107-92-6)
0.1% propionic acid (CAS-Nr. 79-09-4)
0.3% acidic acid
(CAS-Nr. 64-19-7)
1.4% formic acid
(CAS-Nr. 64-18-6)
10% polymeric oxycaproic acid
55% water
~20ppm cobalt
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach
- Mean weight at study initiation: male 187 g, female 183 g
- Housing: 5 per cage
- Diet: Kliba 343
- Water: tap water
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Application of 10ml/kg of an aquaeous solution.
- Doses:
- 5000, 3160, 2150, 681 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing: Individual body weight was performed at the beginning of the study and at weekly interval thereafter.
- Necropsy of survivors performed: yes
- all animals which died during the study were sectioned.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- see free text
- Gross pathology:
- Deceased animals: general congestion, marked emaciation in some cases.
Gastrointestinal tract empty and inflated in some cases. Mucosa of glandular stomach reddened in some cases.
Sacrificed animals: no pathologic findings noted.
Any other information on results incl. tables
Dose (ml/kg bw) |
Mortality in males |
||||
1 day |
2 days |
7 days |
14 days |
21 days |
|
5000 |
0/5 |
0/5 |
1/5 |
1/5 |
1/5 |
3160 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
2150 |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
681 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
Dose (ml/kg bw) |
Mortality in females |
||||
1 day |
2 days |
7 days |
14 days |
21 days |
|
5000 |
0/5 |
0/5 |
1/5 |
2/5 |
2/5 |
3160 |
0/5 |
0/5 |
0/5 |
1/5 |
1/5 |
2150 |
1/5 |
1/5 |
1/5 |
1/5 |
1/5 |
681 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
General signs of toxicity were:
- 5000 mg/kg bw - irregular breathing, apathy, tumbling, piloerection, bad general condition (reversible within 21 days)
- 3160 mg/kg bw - irregular breathing, apathy, tumbling, piloerection, bad general condition (reversible within 5 days)
- 2150 mg/kg bw - irregular breathing, tumbling, piloerection bad general condition (reversible within 5 days)
No symptoms were observed in the 681 mg/kg bw dose group
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An LD50 (oral gavage, rat) of >5000 mg/kg bw was determined, suggesting that Cyclohexane, oxidized, aquous extract is practically non-toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
