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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,9-trioxaundecane-1,11-diol
EC Number:
203-989-9
EC Name:
3,6,9-trioxaundecane-1,11-diol
Cas Number:
112-60-7
Molecular formula:
C8H18O5
IUPAC Name:
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
Test material form:
liquid
Specific details on test material used for the study:
- Purity: about 90%

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
Mean body weight male rabbit: 3.24 kg
Mean body weight female rabbit: 3.21 kg

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye of the same animal
Amount / concentration applied:
0.05 mL
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 8 days
Score:
0
Irritant / corrosive response data:
After 1 hour slight reddening, secretion; after 24 hours slight reddening, after 8 days no irritation.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met