Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 617-779-3 | CAS number: 85940-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Justification for the non-equivalence of the test material to the submission substance identity:
HDI trimer MEKO blocked is always produced and marketed as dissolved in solvent. Thus, the substance is reasonably expected to be handled and used in a form of a mixture of the registered substance in the solvent. The environment is anticipated to be exposed rather to the mixture than to the pure substance. Thus, the testing strategy was designed to take this route of exposure into account and it has been concluded that testing the mixture was more relevant than testing the registered substance as such.
To conclude, ecotoxicological studies were performed on the mixture and as a consequence for endpoint study records, the test material is not ticked when requesting if equivalent to submission substance identity.
Conclusion on classification
Data elements
The registered substance is a poorly water soluble substance. A Log Kow of 1.6 is determined for the registered substance and is an indication of low potential for bioaccumulation which can be used as a BCF data are lacking.
As explained in relevant sections, the ecotoxicological studies were performed on the mixture of the registered substance in the solvent.
The aquatic toxicity dataset is provided here after: Fish: 96h-LC50 = 141.4 mg/L which are attributed to physical effects ; Aquatic Invertebrates: 48h-EC50 > 1.61 mg/L; Algae: 72h-EC50 > 8.1 mg/L. Therefore, acute toxicity is recorded at levels higher than water solubility limit.
The test material was found to degrade up to 9% after 28 days in a screening biodegradation test. The registered substance is thus considered as not readily biodegradable. The hydrolysis study performed on the test material record a half-life of 139 d at pH 7 and 25°C in water and allows concluding that the registered substance does not exhibit any potential for rapid degradation in water.
Reasoning
No hazard classification is requested for the registered substance considering the low potential for acute aquatic toxicity and the low potential for bioaccumulation.
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