Registration Dossier
Registration Dossier
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EC number: 203-561-1 | CAS number: 108-21-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Reliable guideline studies of isopropyl acetate are not available. The following reliable information is available for surrogate substances on the algae S subspicatus:
Ethyl acetate: 96hr EC50: >100mg/l, 5600mg/l
isobutyl acetate: 96hr EC50: 370mg/l. NOEC=95mg/l
The QSAR ECOSAR predicts that the toxicity to algae will be intermediate between the EC50 values for these two substances. As a conservative approach, the value for isobutyl acetate is taken as a proxy for the toxicity of isopropyl acetate
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 370 mg/L
- EC10 or NOEC for freshwater algae:
- 95 mg/L
Additional information
No reliable algal toxicity studies have been identified for isopropyl acetate. Bringmann and Kuhn (1978) reported toxicity threshold values for isopropyl acetate in algae. 8 -day EC3 values were 165 mg/L and 1400 mg/L in S. quadricauda and M. aeruginosa, respectively. The extended 8-day exposure in these studies have been criticized as unreliable as exponential growth cannot be assured over such a period of time. Algal toxicity data have been reported for structurally similar alcohol esters of acetic acid. Reliable studies of ethyl acetate and n-butyl acetate generated EC50 values of 5600 mg/L (48 hr) and 370 mg/L (72 hr), respectively.
Reliable studies are available for members of the alkyl acetate family either side of isopropyl acetate in the homologous series. QSAR modelling suggests that the toxicity of isopropyl acetate will be more than ethyl acetate but less than butyl acetate. On this basis, the available data for butyl acetate will be used as a conservative basis to derive the key parameter for this end point.
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