Registration Dossier
Registration Dossier
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EC number: 203-561-1 | CAS number: 108-21-4
Neurotoxicity
Administrative data
Description of key information
median acute oral narcotic dose (ND50) of 3064 mg/kg
median inhalation dose affecting behaviour (ID50) of 6693mg/m3
Key value for chemical safety assessment
Additional information
De Ceaurriz et al (1983) reported an ID50 value of 1605 ppm (6693 mg/m3) in the mouse 'swimming despair' test. Only limited information was available about this study. Munch (1972) reported a median acute oral narcotic dose (ND50) of 3064 mg/kg for isopropyl acetate in rabbits based on behavioural observations.
Justification for classification or non-classification
Based on limited data available for isopropyl acetate, classification is recommended warning that exposure to high concentrations of isopropyl acetate vapours may cause narcosis. See Section 7.5 also.
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