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Schreurs 2002: The observed slight induction of human estrogen receptor-alpha by BMDBM (10-100 µM) in the in vitro assay could not be confirmed in the in vivo zebrafish assay.
Schreurs 2005: Butyl methoxydibenzoylmethane (BMDBM) showed weak ERa agonism and weak androgen receptor antagonism in in vitro reporter gene assays. These effects were observed by nearly all tested compounds. No influence on the progesterone receptor was observed.

Additional information

Two studies were found that report on endocrine activity of butyl methoxydibenzoylmethane (BMDBM). Two publications of Schreurs et al. (2002 and 2005) stated that slight induction of human estrogen receptor-alpha by BMDBM was observed in vitro. But as all tested substances showed a similar induction of the estrogene receptor which could not be reproduced in an in vivo zebrafish assay, and none of the other publications support this finding, the observed induction of the estrogen receptor remains questionable.

Based on these results it was concluded that BMDBM possesses no endocrine activity.