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Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Remarks:
tests were following as close as possible the GLP guidelines proposed by OECD
Type of method:
flask method
Water solubility:
22.5 µg/L
Temp.:
21.5 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
383.9 µg/L
Temp.:
21.6 °C
pH:
6.05
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
373.1 µg/L
Temp.:
21.5 °C
pH:
6.04
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
322.8 µg/L
Temp.:
21.6 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
306.4 µg/L
Temp.:
21 °C
pH:
6
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
267.3 µg/L
Temp.:
22.4 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 672 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
234 µg/L
Temp.:
21.2 °C
pH:
5.89
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 833 µg/L
Temp.:
22 °C
pH:
6.43
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 780 µg/L
Temp.:
21.4 °C
pH:
6.44
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 461 µg/L
Temp.:
21.3 °C
pH:
6.61
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of CoCO3 is 267.3 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of CoCO3 is 3303.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of CoCO3 is 22262.0.8 µg/L at 100 mg/L loading for the 7-day endpoint.

Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on CoCO3 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on CoCO3 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of CoCO3 is 267.3 µg/L for the 28 -day endpoint (1 mg/L loading), 3303.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 22262.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Remarks:
tests were following as close as possible the GLP guidelines proposed by OECD
Type of method:
flask method
Water solubility:
3 303 µg/L
Temp.:
21.7 °C
pH:
6.43
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
1 729 µg/L
Temp.:
21.5 °C
pH:
5.85
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
19 121 µg/L
Temp.:
21.3 °C
pH:
6.93
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
21 435 µg/L
Temp.:
20.7 °C
pH:
6.73
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
20 940 µg/L
Temp.:
21.3 °C
pH:
6.61
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
22 262 µg/L
Temp.:
20.4 °C
pH:
6.9
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of CoCO3 is 267.3 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of CoCO3 is 3303.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of CoCO3 is 22262.0.8 µg/L at 100 mg/L loading for the 7-day endpoint.

Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on CoCO3 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on CoCO3 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of CoCO3 is 267.3 µg/L for the 28 -day endpoint (1 mg/L loading), 3303.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 22262.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Remarks:
The tests were following as close as possible the GLP guidelines proposed by OECD
Type of method:
flask method
Water solubility:
22.5 µg/L
Temp.:
21.5 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
383.9 µg/L
Temp.:
21.6 °C
pH:
6.05
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
373.1 µg/L
Temp.:
21.5 °C
pH:
6.04
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
322.8 µg/L
Temp.:
21.6 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
306.4 µg/L
Temp.:
21 °C
pH:
6
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
267.3 µg/L
Temp.:
22.4 °C
pH:
6.06
Remarks on result:
other: CoCO3 concentration at 672 hour sampling time at 1 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
234 µg/L
Temp.:
21.2 °C
pH:
5.98
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 833.4 µg/L
Temp.:
22 °C
pH:
6.04
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 780 µg/L
Temp.:
21.4 °C
pH:
6.44
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
3 461 µg/L
Temp.:
21.3 °C
pH:
6.61
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of CoCO3 is 267.3 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of CoCO3 is 3303.4 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of CoCO3 is 22262.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:

A

 
seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on CoCO3 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on CoCO3 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of CoCO3 is 267.3 µg/L for the 28 -day endpoint (1 mg/L loading), 3303.4 µg/L for the 7 -day endpoint (10 mg/L loading) and 22262.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Remarks:
The tests were following as close as possible the GLP guidelines proposed by OECD
Type of method:
flask method
Water solubility:
3 303.4 µg/L
Temp.:
21.7 °C
pH:
6.43
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 10 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
1 729 µg/L
Temp.:
21.5 °C
pH:
5.85
Remarks on result:
other: CoCO3 concentration at 0 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
19 121.5 µg/L
Temp.:
21.3 °C
pH:
6.93
Remarks on result:
other: CoCO3 concentration at 24 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
21 434.5 µg/L
Temp.:
20.7 °C
pH:
6.73
Remarks on result:
other: CoCO3 concentration at 48 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
20 939.8 µg/L
Temp.:
21.3 °C
pH:
6.61
Remarks on result:
other: CoCO3 concentration at 96 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Water solubility:
22 262 µg/L
Temp.:
20.4 °C
pH:
6.9
Remarks on result:
other: CoCO3 concentration at 168 hour sampling time at 100 mg/L loading. Sample analysis was conducted in triplicate per test vessel (3 test vessels per loading). Average value from the tests is given.
Details on results:
For 100 mg/L loadings: The sample increased the pH beyond the buffering capacity of the system used by the protocol, increasing the CO2 to higher flow rate decrease the pH, but not reaching the required 6, with the results of pH of around 5 in the blanks. Therefore as recommended in the protocol the pH was let to drift and the change in pH should be considered an intrinsic property of the substance.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of CoCO3 is 267.3 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of CoCO3 is 3303.4 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of CoCO3 is 22262.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:

A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on CoCO3 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on CoCO3 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of CoCO3 is 267.3 µg/L for the 28 -day endpoint (1 mg/L loading), 3303.4 µg/L for the 7 -day endpoint (10 mg/L loading) and 22262.0 µg/L for the 7 -day endpoint (100 mg/L loading).

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-09-19 to 2007-03-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study - The stability of the test substance is missing.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
, 1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
signed 2005-11
Type of method:
column elution method
Water solubility:
>= 9.87 - <= 12.99 µg/L
Temp.:
20 °C
pH:
>= 7.55 - <= 7.94
Water solubility:
>= 2.96 - <= 4.26 µg/L
Temp.:
37 °C
pH:
>= 7.32 - <= 7.95
Details on results:
Total elution times were about 94hours at 20°C and 94 and 97 hours at 37°C. The measured results differ by less than 30%. Therefore, the study is considered to be valid.

The sample measurement was performed by AAS.

AAS-Conditions:

Apparatus:                     AAS PE 2100

Technique:                     Flame

Lamp:                            Cobalt

Wavelength:                   240.7nm

Slit width:                       0.2

Read time [s]:                 0.5

Read delay [s]:               0

Signal type:                    AA

Signal measurement:      Time Average

Flame Type:                    Air/C2H2

Oxidant Flow [L/min]:     8.0

Fuel Flow [L/min]:           2.5

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of Cobalt carbonate was found to be at 20°C 12.98 µg/L (+/-1.81 µg/L) and at 37°C 4.25µg/L (+/-0.58 µg/L)using the column elution method

Description of key information

The water solubility of Cobalt carbonate is given at 20°C: 12.98 µg/L (+/-1.81 µg/L) and at 37°C: 4.25µg/L (+/-0.58 µg/L)

Key value for chemical safety assessment

Water solubility:
12.98 µg/L
at the temperature of:
20 °C

Additional information