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EC number: 208-169-4 | CAS number: 513-79-1
Results after treatment with cobalt carbonate:
Absorbance 570 nm Tissue 1
Absorbance 570 nm Tissue 2
Absorbance 570 nm Tissue 3
Mean Absorbance of 3 Tissues
Absorbance [%] Tissue 1, 2 + 3
Standard Deviation [%]
[% of Negative Control]
Number of Studies
July 2007-June 2010
Range of Viabilities
Range of ODs
Table 1. Eye irritation scores in New Zealand White rabbits following application of 0.1 gram of cobalt carbonate powder followed in 30 seconds by irrigation with 200 mls of lukewarm tap water
Mean animal #4
24, 48, and 72 hours
Eyes rinsed after 30 seconds
Mean animal #5
Mean animal #6
Reference Heppenheimer (2011) is considered as the key study for skin irritation and will be used for classification. The mean relative absorbance (% of the negative control, correlating with mean tissue viability) after 15 minutes incubation in the in vitro human skin model test (EpiSkin, according to OECD TG 439) was 99.6%. The classification criteria according to regulation (EC) 1272/2008 as skin irritant are not met, since the mean tissue viability was above the threshold for skin irritants of 50.0%. No classification required.
Reference Vinegar (1977) is considered as the key study for eye irritation and will be used for classification. The overall irritation results 24, 48 and 72h after application per animal are as follows:
Corneal opacity: mean score=0.0 for all 3 animals
Iritis: mean score=0.0 for all 3 animals
Conjunctival redness: 0.33, 0.67, 1.0
Conjunctival oedema (chemosis): 0.0 for all 3 animals
The classification criteria acc. to regulation (EC) 1272/2008 as irritating to eyes are not met, since none of the 3 animals showed after 24, 48 and 72hours a conjunctival and chemosis score of 2.0 and above, or a cornea and iritis score of 1.0 and above, thus cobalt carbonate will not be classified.
The justification for classification as respiratory irritant is covered under the endpoint specific target organ toxicity- single exposure: inhalation as given in the acute toxicity section.
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