Registration Dossier
Registration Dossier
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EC number: 200-867-7 | CAS number: 75-38-7
Carcinogenicity
Administrative data
Description of key information
Two lifetime inhalation studies in rats (2 years) and mice (18 months) showed no significant treatment-related adverse non-carcinogenic or carcinogenic effect at the highest concentration tested (10000 ppm; 26000 mg/m3). Vinylidene fluoride is not considered to have carcinogenic effects based on the experimental data available.
Key value for chemical safety assessment
Carcinogenicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 26 000 mg/m³
Justification for classification or non-classification
Based on the absence of neoplastic lesions in rats exposed to concentrations up to 10000 ppm (26000 mg/m3) for 2 years, classification of vinylidene fluoride for carcinogenicity is not warranted according to EU Directive 67/548/EEC andEU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Two lifetime inhalation studies in rats (2 years, TNO (1991)) and mice (18 months, Bio/dynamics Inc. (1991)) showed no significant treatment-related adverse non-carcinogenic or carcinogenic effects at the highest dose tested (10000 ppm; 26000 mg/m3).
Based on the experimental data available, VDF is not considered to have carcinogenic effects.
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