Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acrylate and methacrylate esters: Relationship of hemolytic activity and in vivo toxicity.
- Author:
- Dillingham EO et al.
- Year:
- 1 983
- Bibliographic source:
- J. Biomed. Mat. Res. 17: 945-957
Materials and methods
- Principles of method if other than guideline:
- According to Higuchi and Davis(1970) and Dillingham et al. (1973).
- GLP compliance:
- not specified
- Type of method:
- in vitro
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- Methyl acrylate, no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
- Details on results:
- The concentration effecting 50 % hemolysis in rabbit erythrocytes in vitro was determined to be 20 g/L (0.23 mole/L).
Applicant's summary and conclusion
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