Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1930
Report date:
1930

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl prop-2-enoate
Details on test material:
methyl acrylate, not further specified

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Duration of treatment / exposure:
up to 5 injections / week
Doses / concentrations
Remarks:
Doses / Concentrations:
50; 100; 200; 300; 400; 500 mg/kg bw; in an "oily solution"
No. of animals per sex per dose:
50 - 400 mg/kg bw: 1 animal per dose
500 mg/kg bw: 2 animals
Control animals:
no
Details on study design:
Post-exposure period: not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Mortality and clinical signs:
500 mg/kg: lethal for 2 animals after the first injection
(time to death: 4 hours to 1 day), clinical signs:
convulsions, irregular breathing, lateral position.
400 mg/kg: lethal after second injection; no specific
clinical signs after first injection (hyperactivity),
convulsions after 2nd injection.
300 mg/kg (2 injections): no mortality, no clinical signs
200 mg/kg (3 injections): no mortality, no clinical signs
100 mg/kg (5 injections): no mortality, no clinical signs
50 mg/kg (5 injections): no mortality, no clinical signs

Applicant's summary and conclusion