Registration Dossier
Registration Dossier
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EC number: 203-625-9 | CAS number: 108-88-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, QSAR model validation study, published in peer reviewed literature, no restrictions, fully adequate for assessment.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- A simple dermal absorption model: Derivation and application
- Author:
- ten Berge, W.
- Year:
- 2 009
- Bibliographic source:
- Chemosphere, 75, 1440-1445
Materials and methods
- Principles of method if other than guideline:
- Dermal absorption was predicted using a model based on QSAR.
- GLP compliance:
- no
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
Constituent 1
Results and discussion
Percutaneous absorption
- Parameter:
- percentage
- Absorption:
- 3.6 %
- Remarks on result:
- other: maximum dermal flux = 0.000581 mg/cm2/min
Applicant's summary and conclusion
- Conclusions:
- Dermal absorption of toluene was predicted using the model of ten Berge to be approximately 3.6% with a predicted maximum flux of 0.000581mg/cm2/min.
- Executive summary:
The dermal absorption of toluene was predicted using a model which considers dermal absorption as a two stage process, permeation of the stratum corneum followed by transfer from the stratum corneum to the epidermis. The QSAR for each process was derived by fitting each model equation to experimentally derived values using an iterative non-linear least squares approach. Dermal flux and percent absorption were predicted using physicochemical values (see section 4) using values determined at approximately 25C.
The model predicted a maximum flux = 0.0000581 mg/cm2/min giving an absorption of approximately 3.6%.
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