Registration Dossier
Registration Dossier
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EC number: 203-625-9 | CAS number: 108-88-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study pre-dates GLP and guideline development and has limitations in design and reporting but otherwise acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Streigel JA and Nycum JS,
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- Study investigated mortality in groups of 4 male rabbits exposed for 24 hours. No further details are provided but gives adequate relative guide to LD50.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Details on test material:
- - no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
No other data provided
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- - no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- 95% CL:
- 9.63 - 20.77
- Remarks on result:
- other: LD50 quoted as 14.1 mL/kg (12267 mg/kg using density of 0.87)
Any other information on results incl. tables
LD50 quoted as 14.1 mL/kg (9.63 -20.77)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 value of 14.1 mL/kg (9.63-20.77), corresponding to 12267 g/kg (8.38-18.07).
- Executive summary:
Acute dermal toxicity in the rabbit was found to be low (LD50 >5000 mg/kg). Toluene does not warrant classification under GHS / CLP.
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