Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-670-8 | CAS number: 13463-40-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
BASF (1995) reported a 28-day inhalation toxicity study. Male and female rats were offered vapour concentrations of 0.1 ppm = ca. 0.8 mg/m3 (test group 4), 0.3 ppm = ca. 2 mg/m3 (test group E), 1 ppm = ca. 8 mg/m3 (test group 1), 3 ppm = ca. 24 mg/m3 (test group 2) and 10 ppm = ca. 81 mg/m3 (test group 3). The frequency of treatment was 5 days per week and 6 hours per day (totally up to 20 exposures). The following findings were obtained: One exposure to 10 ppm (test group 3) caused 100% lethality and 2 exposures to 3 ppm (test group 2) 50% lethality (3 male and 2 female animals) during a period of 4 days. In test group 3 (10 ppm) the animals showed symptoms of respiratory distress and irritation as well as reduced general state. Pathological examinations revealed signs of irritation in the upper respiration tract and severe lung damage. In some animals lymphocyte depletion of the spleen occurred.
In test group 2 (3 ppm) the surviving animals showed accelerated respiration up to study day 9. No influence on body weight development was seen in the post-exposure observation period. No substance-related changes in hematological or clinico-chemical parameters occurred. The same kind of lung damage as in test group 3 was found during pathological examination in the animal that died or were sacrificed prematurely. The surviving animals still showed increased absolute and relative lung weights and some histopathologic changes in the lungs at the end of the study period.
No substance-related clinical signs and findings or influence on body weight development were seen in test groups 4, E and 1. No substance-induced effects on hematological and clinicochemical parameters occurred besides a slight but mostly statistically significant elevation of CO-hemoglobin levels which is not considered as of toxicologial relevance. Pathological evaluation also did not reveal any morphological alterations besides a slight but statistically significant increase in absolute and relative lung weights of the male animals of test group 1 ppm. The NOAEC was found to be 2 mg/m3 (= 0.3 ppm).
The above-mentioned BASF study was based on an older investigation of Gage (1970). Male and female rats were offered daily (5.5 h/d) vapour concentrations of 15 ppm (2 days) or 7 ppm (18 days). In the high dose group, 4 rats died within 3 - 4 days; lethargy, respiratory difficulties, formation of 0.2 - 0.4% carboxyhemoglobin, lung edema, and congestion was observed. In the low dose group, no signs of toxicity were observed; organs appeared to be normal. The NOAEC was found to be 55 mg/m3.
Justification for classification or non-classification
Classification proposal regarding EU criteria: R48/23. GHS criteria: Cat. 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)