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EC number: 205-480-7 | CAS number: 141-32-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF test: In principle, the methods described in OECD Guideline 401 were used.
5-10 rats per dose were treated by gavage with preparations of the test substance in 10 % traganth. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Aqueous traganth emulsion
- Doses:
- 2.040, 3.160 and 5.010 ml/kg bw (corresponding to 1840, 2840 and 4510 mg/kg bw) Calculation of concentrations (mg/kg bw) based on density of the test substance (0.90 g/ml).
- No. of animals per sex per dose:
- 5-10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 150 mg/kg bw
- Mortality:
- One, 2 and 8 animals died in the dose groups of 1832, 2838 and 4500 mg/kg bw, respectively.
- Clinical signs:
- other: 1832 mg/kg bw: only piloerection on the day after substance administration 2838 mg/kg bw: piloerection, staggering gait, one rat had diarrhea 4500 mg/kg bw: piloerection, labored breathing, abdominal position, crawling gait.
- Gross pathology:
- 1832 mg/kg bw: mottled lung surface, thymus haemorrhagic, spleen congested
2838 and 4500 mg/kg bw: hyperemia of medulla renalis was observed. - Other findings:
- - Histopathology: low grade of fatty degeneration was observed in liver of one animal in 2838 mg/kg bw dose group.
Any other information on results incl. tables
Dose (mg/kg bw) |
No. of animals |
Mortality |
|||
1 h |
24 h |
48 h |
7 days |
||
1832 |
5 |
0/5 |
1/5 |
1/5 |
1/5 |
2838 |
5 |
0/5 |
2/5 |
2/5 |
2/5 |
4500 |
10 |
0/10 |
4/10 |
8/10 |
8/10 |
Original value reported: LD50 = 3.5 ml/kg bw (corresponding to ca. 3150 mg/kg bw)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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