Butyl acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF test: In principle, the methods described in OECD Guideline 401 were used.
5-10 rats per dose were treated by gavage with preparations of the test substance in 10 % traganth. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butyl acrylate

EC Number:

205-480-7

EC Name:

Butyl acrylate

Cas Number:

141-32-2

Molecular formula:

C7H12O2

IUPAC Name:

butyl prop-2-enoate

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Aqueous traganth emulsion

Doses:

2.040, 3.160 and 5.010 ml/kg bw (corresponding to 1840, 2840 and 4510 mg/kg bw) Calculation of concentrations (mg/kg bw) based on density of the test substance (0.90 g/ml).

No. of animals per sex per dose:

5-10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 3 150 mg/kg bw

Mortality:

One, 2 and 8 animals died in the dose groups of 1832, 2838 and 4500 mg/kg bw, respectively.

Clinical signs:

other: 1832 mg/kg bw: only piloerection on the day after substance administration 2838 mg/kg bw: piloerection, staggering gait, one rat had diarrhea 4500 mg/kg bw: piloerection, labored breathing, abdominal position, crawling gait.

Gross pathology:

1832 mg/kg bw: mottled lung surface, thymus haemorrhagic, spleen congested
2838 and 4500 mg/kg bw: hyperemia of medulla renalis was observed.

Other findings:

- Histopathology: low grade of fatty degeneration was observed in liver of one animal in 2838 mg/kg bw dose group.

Any other information on results incl. tables

Dose (mg/kg bw)	No. of animals	Mortality
		1 h	24 h	48 h	7 days
1832	5	0/5	1/5	1/5	1/5
2838	5	0/5	2/5	2/5	2/5
4500	10	0/10	4/10	8/10	8/10

Original value reported: LD50 = 3.5 ml/kg bw (corresponding to ca. 3150 mg/kg bw)