Registration Dossier
Registration Dossier
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EC number: 245-205-8 | CAS number: 22766-83-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 68.1 - 71.7% after 28 d (OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of
2-octyldodecyl myristate (CAS 22766-83-2) are available for this
endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a
read across to the structurally related source substance 2-octyldodecyl
isooctadecanoate (CAS 93803-87-3) was conducted. The read-across
substance 2-octyldodecyl isooctadecanoate is characterised by a longer
fatty acid chain length (C18 iso branched) and by the same alcohol
component (2-octyldodecan-1-ol). Based on the structure the source
substance can be used for read-across purposes as a worst case approach
since the chain length of the fatty alcohol and the fatty acid are the
determining factors for biodegradation.
The study with the source substance 2-octyldodecyl isooctadecanoate was
performed according to OECD 301B under aerobic conditions using domestic
activated sludge as inoculum (Desmares-Koopmans, 1998). A test substance
concentration of approx. 14.5 mg/L was degraded to an extent of 68.1 -
71.7% after 28 d. Since 2-octyldodecyl isooctadecanoate is a UVCB
substance and consists of structurally similar constituents with [e.g.
different chain-lengths, degree and/or site of branching or
stereo-isomers], sequential (instead of concurrent) biodegradation of
the individual structures can take place, but all can be considered as
readily biodegradable. Thus, referring to Annex I of the OECD Guideline
for Testing of Chemicals ‘Revised introduction to the OECD guidelines
for testing of chemicals, section 3’ (OECD, March 2006), the 10-day
window should not be considered for this UVCB substance and due to a
degradation of >60 % within 28 days the substance can be regarded as
readily biodegradable. Moreover, the test substance is assumed not to be
inhibitory to activated sludge microorganisms based on a biodegradation
of > 25% in the toxicity control after 14 d.
Based on the results from one structurally related source substance (in
accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be
concluded that 2-octyldodecyl myristate is readily biodegradable
according to the OECD criteria.
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