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Short-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility.

Key value for chemical safety assessment

Additional information

Since no studies investigating the short-term toxicity of 2-octyldodecyl myristate (CAS 22766-83-2) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was conducted. The source substance is representative to evaluate the short-term toxicity of the target substance to fish. The target substance is characterised as an ester of C18 iso branched fatty acid esterified with 2-octyldodecan-1-ol. The source substance is structurally very similar to the target substance. 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) is characterised by a longer fatty acid chain length (C18 iso branched) and by the same alcohol component (2-octyldodecan-1-ol).
This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.

The study with the source substance 2-octyldodecyl isooctadecanoate investigated the short-term toxicity to aquatic invertebrates (Bogers, 1998). The study was performed according to OECD 202 (GLP) with the water flea Daphnia magna. A Water Accommodated Fraction (WAF) of nominal 86 mg/L was prepared and tested under static conditions (limit test). A chemical analysis of the test substance concentrations in the test vessels was not possible since no applicable method could be established due to the very low water solubility to detect test concentrations. No immobilisation was observed after 48 h and therefore an EL50 of > 86 mg/L (nominal) was derived.

Based on the available result from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterised by a comparable structure, it can be concluded that 2-octyldodecyl myristate will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.