Diisopropyl adipate

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.004 mg/L

Assessment factor:

1 000

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.036 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0 mg/L

Assessment factor:

10 000

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

1 000 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

no hazard identified

Sediment (marine water)

Hazard assessment conclusion:

no hazard identified

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

1 mg/kg soil dw

Assessment factor:

1 000

Extrapolation method:

assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Additional information

According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met.

Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”.

Since the group concept is applied to the category members of the PFAE linear, data will be generated from a representative category member to avoid unnecessary animal testing. Additionally, once the group concept is applied, substances will be classified and labelled on this basis.

Conclusion on classification

Classification related key information

Log Kow: 3.2 (KOWWIN v1.68)

Water solubility: 180 mg/L (SRC Physprop Database)

Biodegradation: 90 % in 14 days (OECD 301C), read across

BCF: 6.3 L/kg (BCFBAF v3.01; Arnot-Gobas estimate) 

Aquatic acute toxicity:

For fish: 96h, LC50 (P. promelas): 3.64 mg/L (OECD 203), read across

For algae: 72h, EC50 (P. subcapitata): 5.16 mg/L (OECD 201), read across

For crustacea: 24h, EC50 (D. magna): 16.6 mg/L (OECD 202), read across

Aquatic chronic toxicity:

For fish: no data

For algae: 72h, NOEC (P. subcapitata): 3 mg/L (OECD 201), read across

For crustacea: no data

Non-Classification justification according to CLP

Based on the data above, the acute aquatic toxicity L(E)C50 is > 1 mg/L for fish, algae and aquatic invertebrates. Diisopropyl adipate (CAS 6938-94-9) does not need to be classified and labelled as acute aquatic hazard according to the 2nd ATP of the Regulation (EC) No.1272/2008 (CLP).

Diisopropyl adipate (CAS 6938-94-9) is considered to be rapidly degradable. Valid chronic toxicity data are available for algae – the lowest NOEC is > 1 mg/L. Diisopropyl adipate (CAS 6938-94-9) does not need to be classified and labelled as environmental hazard according to the 2nd ATP of the Regulation (EC) No.1272/2008 (CLP).

M-factor for chronic aquatic toxicity: -

Non-Classification justification according to DSD

Based on the data above, Diisopropyl adipate (CAS 6938-94-9) is rapidly degradable and is considered to have a low potential for accumulation. The acute aquatic toxicity L(E)C50 is > 1 mg/L in water for fish, algae and daphnia. Therefore, Diisopropyl adipate (CAS 6938-94-9) does not need to be classified and labelled as environmental hazard according to Directive 67/548/EEC.