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EC number: 201-877-4 | CAS number: 89-04-3
A structural analogue of the substance (1,2,4 -Benzenetricarboxylic acid, decyl octyl ester) was examined for mutagenic activity by assaying for the induction of 5 -trifluorothymidine resistant mutants in mouse lymphoma L5178Y cells after in vitro treatment, in the absence and presence of S9 metabolic activation, using a fluctuation method. The study was designed to comply with the experimental methods indicated in: Test method B.17 "in vitro mammalian cell gene mutation test" described in Council Regulation (EC) No. 440/2008 and OECD Guideline for the testing of chemicals No. 476.
No relevant increases in mutant frequencies were observed following treatment with the test item, in the absence or presence of S9 metabolism and it was concluded that the substance does not induce mutation at the TK locus of L5178Y mouse lymphoma cells in vitro in the absence or presence of S9 metabolic activation, under the reported experimental conditions.
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