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EC number: 217-288-0 | CAS number: 1800-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 2017 to November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
- Specific details on test material used for the study:
- - Appearance: Clear colourless liquid
- Test item storage: At room temperature protected from light
- Purity/Composition correction factor: No correction factor required - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 1 200 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 1 900 Pa
- Conclusions:
- The vapour pressure of the test item was determined to be 1200 Pa at 20°C and 1900 Pa at 25°C.
- Executive summary:
The vapour pressure of the test item was determined in a GLP-compliant study performed in accordance with EC A.4 method and OECD Guideline No. 104, using the isothermal thermogravimetric (TGA) effusion method.
The vapour pressure of the test item was determined to be 1200 Pa at 20°C and 1900 Pa at 25°C.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From November 2015 to December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was well documented and performed according to recognized guidelines. No deviation from the guideline was observed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- static method
- Temp.:
- 20.03 °C
- Vapour pressure:
- 10.647 mBar
- Remarks on result:
- other: Mean of 3 measurements
- Temp.:
- 25.36 °C
- Vapour pressure:
- 12.468 mBar
- Remarks on result:
- other: Mean of 3 measurements
- Temp.:
- 30.76 °C
- Vapour pressure:
- 14.672 mBar
- Remarks on result:
- other: Mean of 3 measurements
- Temp.:
- 39.95 °C
- Vapour pressure:
- 18.833 mBar
- Remarks on result:
- other: Mean of 3 measurements
- Temp.:
- 49.37 °C
- Vapour pressure:
- 24.234 mBar
- Remarks on result:
- other: Mean of 3 measurements
- Transition / decomposition:
- no
- Conclusions:
- The vapor pressure of the test item is measured at 10.647 mbar at 20°C and 12.468 mbar at 25°C.
- Executive summary:
The vapor pressure was determined with the static method according to recognized guidelines (EU A.4 Method and OECD 104 Guideline). No deviation from the guideline was observed during the study.
With this process, at thermodynamic equilibrium, the vapor pressure established in a closed system is determined at a specified temperature. The sample was degassed at 20°C before measurement of the vapor pressure.
The vapor pressure was measured at 10.647 mbar at 20°C and 12.468 mbar at 25°C.
Referenceopen allclose all
The vapour pressure regression curve of the log PT of the test item as function of the reciprocal temperatures. The equation of the curve was: log PT = -3344 × 1/T + 14.49 (r = 0.993, n = 8).
Table 1: Results of the Vapour pressure Isothermal TGA Analysis
Temperature [°C] |
Weight loss [µg/min] |
νT [g/cm2/h] |
log νT |
log PT |
PT [Pa] |
27.5 |
340.300 |
4.06 x 0.01 |
-1.39 |
3.36 |
2.3 x 1000 |
|
346.036 |
4.13 x 0.01 |
-1.38 |
3.37 |
2.3 x 1000 |
30 |
400.625 |
4.78 x 0.01 |
-1.32 |
3.45 |
2.8 x 1000 |
|
417.893 |
4.99 x 0.01 |
-1.30 |
3.47 |
3.0 x 1000 |
32.5 |
481.318 |
5.75 x 0.01 |
-1.24 |
3.55 |
3.5 x 1000 |
|
492.149 |
5.87 x 0.01 |
-1.23 |
3.56 |
3.6 x 1000 |
35 |
569.397 |
6.80 x 0.01 |
-1.17 |
3.64 |
4.4 x 1000 |
|
543.392 |
6.49 x 0.01 |
-1.19 |
3.62 |
4.1 x 1000 |
Table 2: Vapour Pressure of the Test Item
Temperature[°C] |
log PT |
PT[Pa] |
PT [mm Hg] |
20 |
3.08 |
1200 |
9.0 |
25 |
3.27 |
1900 |
14 |
The uncertainty of measurement for pressure is about 0.8 mbar and 0.05°C for the temperature.
The value obtained between 20.03 to 49.37°C are used to regress the coefficient of Antoine's law using the following equation:
Ln P = A + [ B / (T +C) ]
With P in mbar and T in K
The error involved by the modeling of vapor pressure with the determined Antoine's law is about 0.1 mbar which is in magnitude of the uncertainty of measurement of pressure (0.8 mbar).
The calculated vapor pressure values (with Antoine's law coefficient) are compared to the experimental data obtained during the study.
The results are shown in the table below.
Temperature (°C) | Vapor pressure measured Pexp (mbar) | Vapor pressure calculated Pcalc (mbar) | Pexp-Pcal (mbar) |
20.03 | 10.647 | 10.65 | 0.01 |
25.36 | 12.468 | 12.49 | 0.02 |
30.76 | 14.672 | 14.61 | 0.06 |
39.95 | 18.833 | 18.88 | 0.04 |
49.37 | 24.234 | 24.22 | 0.01 |
The experimental and the calculated vapor pressures are consistent between them.
Description of key information
The vapour pressure of the test item was determined in a GLP-compliant study performed in accordance with EC A.4 method and OECD Guideline No. 104, using the isothermal thermogravimetric (TGA) effusion method. The vapour pressure of the test item was determined to be 1200 Pa at 20°C and 1900 Pa at 25°C.
These experimental values are further supported by a non-GLP study, performed according to the same recognized guideline than in the key study (OECD 104) and reporting a vapour pressure of 1065 Pa at 20°C.
In a disregarded study, the vapor pressure was estimated to be 216 Pa at 25°C. This data was obtained by extrapolation of data obtained at highest temperature (96 to 120°C approximately)
Key value for chemical safety assessment
- Vapour pressure:
- 1 200 Pa
- at the temperature of:
- 20 °C
Additional information
The vapour pressure of the test item was investigated in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint. A non-GLP study is also reported for the endpoint and selected as supporting study (Klimisch 1).
In the disregarded study, the vapor pressure at 25°C was obtained by extrapolation of plots relating the logarithm of Vapor pressure (in Pa) and the inverse of the temperature (in K). These plots were built using vapor pressure measured at high temperatures. It is specified in international recognized guidelines (EU A.4 Method and OECD 104 guideline), that the relation between the vapor pressure and the inverse of the temperature is a linear function only on a limited range of temperature.
We have checked the validity of plots extrapolation by calculating the vapor pressure at 135°C (which is the boiling temperature of the test item). Indeed, the plots have been determined with data obtained at temperatures closed to the boiling point. Based on recognized guidelines (OECD 103 guideline and EU A.2 Method), we know that the vapor pressure of a substance is equal to the atmospheric pressure (101,325 kPa) at the boiling temperature.
So we calculated (with the equation obtained at each run) the vapor pressure at 135°C. The values obtained with the 3 equations are not consistent with the expected vapor pressure value at the boiling point. In a temperature range near to the temperatures used to obtain the plots (relating vapor pressure and temperature), the extrapolated vapor pressure is very different from the expected value.
We can conclude that the extrapolation at temperature far from the one used for the plots will give more irrelevant results and therefore the extrapolated values are considered unreliable.
As a confirmation, the extrapolation at 25°C of the vapor pressure using the equation obtained from the 3 experimental runs is inconsistent with the experimental vapour pressure values obstained in the key and supporting studies.
Because of the above the study was disregarded.
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