Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Toxic effect type:
dose-dependent

Effects on fertility

Description of key information

In an OECD 422 screening study conducted in rats administered 1,6-divinylperfluorohexane by the oral route (gavage) at up to 1000 mg/kg/day, there were no substance-related findings indicative of adverse effects on the reproductive organs, or reproduction parameters.

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available

Effects on developmental toxicity

Description of key information

In an OECD 422 screening study conducted in rats administered 1,6-divinylperfluorohexane by the oral route (gavage) at up to 1000 mg/kg/day, there were no substance-related findings indicative of adverse effects on the pre- or postnatal development.

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the absence of adverse effects on the reproductive parameters and development in the available study, 1,6-Divinylperfluorohexane does require classification for reproductive toxicity according to the criteria of the CLP Regulation EC No. 1272/2008.

Additional information