Registration Dossier
Registration Dossier
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EC number: 205-406-3 | CAS number: 140-26-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authoritative source
Data source
Reference
- Reference Type:
- publication
- Title:
- Phenylethyl Alcohol, Aldehyde, Acid and Related Acetals and Esters and Related Substances
- Author:
- Dr A. Mattia and Professor A.G. Renwick
- Year:
- 2 003
- Bibliographic source:
- WHO FOOD ADDITIVES SERIES: 50, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Principles of methods not mentioned in the publication
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl isovalerate
- EC Number:
- 205-406-3
- EC Name:
- Phenethyl isovalerate
- Cas Number:
- 140-26-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-phenylethyl 3-methylbutanoate
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- CAS No: 140-26-1Chemical name Phenethyl isovalerateNature of chemical: Organic
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: No data
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data
Administration / exposure
- Route of administration:
- other: No Data
- Vehicle:
- not specified
- Details on exposure:
- No Data
- Duration and frequency of treatment / exposure:
- No Data
Doses / concentrations
- Remarks:
- Doses / Concentrations:No Data
- No. of animals per sex per dose / concentration:
- No Data
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- There is no data pertaining to absorption of the test chemical.
- Type:
- distribution
- Results:
- There is no data pertaining to distribution of the test chemical.
- Type:
- metabolism
- Results:
- Phenethyl ester is rapidly hydrolysed in vivo to yield phenethyl alcohol. Phenethyl alcohol is then oxidized to phenylacetic acid.
- Type:
- excretion
- Results:
- All the flavouring agents were predicted to hydrolyse and/or oxidize to yield phenylacetic acid or a phenoxyacetic acid derivative that is excreted either free or in conjugated form primarily in the urine.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- phenethyl alcoholphenylacetic acid
Any other information on results incl. tables
All the flavouring agents in this group were predicted to hydrolyse and/or oxidize to yield phenylacetic acid or a phenoxyacetic acid derivative that is excreted either free or in conjugated form primarily in the urine.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study resultsBased on the information in the present report as well as a report by the European food safety authority (EFSA) on Phenethyl isovalerate (which belongs to the category of Phenethyl ester), no safety concern was identified at estimated levels of intake as flavouring substance based on the Maximised Survey-derived Daily Intake (MSDI) approach. The present data which indicates metabolism to relatively non-toxic metabolites and excretion primarily in the urine also suggests that the chemical is eliminated from the living system after metablism; thereby indicating a low bio-accumulation potential.
- Executive summary:
There is no data available on the toxicokinetic profile conducted in vivo on specific animal for the target chemicalPhenethyl isovalerate. From the details available in theEuropean food safety authority (EFSA) opinion document onPhenethyl isovalerate as well as in the WHO food additive series 50 (pertaining to the category of Phenethyl ester, in which the target chemical qualifies; it is observed that upon entry within the human body the chemical is metabolizedto relatively non-toxic metabolites and eliminated out of the human body via excretion primarily in the urine. This, based on this information it can be concluded that the chemicalPhenethyl isovalerate is likely to exhibit a low bio-accumulation potential.
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