Registration Dossier
Registration Dossier
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EC number: 205-406-3 | CAS number: 140-26-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials – Phenethyl Isovalerate
- Author:
- Levenstein
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Pages 961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To determine the acute oral toxicity of phenethyl isovalerate in rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl isovalerate
- EC Number:
- 205-406-3
- EC Name:
- Phenethyl isovalerate
- Cas Number:
- 140-26-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-phenylethyl 3-methylbutanoate
- Details on test material:
- - Name of test material (as cited in study report):Phenethyl isovalerate- Molecular formula (if other than submission substance):C13H1802- Molecular weight (if other than submission substance): 206.28 g/mol- Substance type:Organic- Physical state:Liquid- Analytical purity: No data available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortalaity was noted at 5000 mg/Kg bw
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- In an acute oral LD50 study in rats, the LD50 for phenethyl isovalerate > 5000mg/kg
- Executive summary:
In an acute oral LD50 study in rats, the LD50 for phenethyl isovalerate > 5000mg/kg.Based on the above value ,the test material does not classify as an acute oral toxicant.
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