Registration Dossier
Registration Dossier
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EC number: 930-964-6 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Monochloroacetic acid: Key studies: experimental results: Two studies with Scenedesmus subspicatus were independently performed at two different laboratories. The obtained results for biomass and growth were within the same range, i.e. 25-28 μg/l for biomass and 30-70 μg/l for growth (48-72 hour EC50-values).
Methyl chloroacetate: Key study: Read-across from analogue: the 48-h EC50 for methyl chloroacetate is calculated to be 18.33 mg/l.
Key value for chemical safety assessment
Additional information
Reaction mass of methyl chloroacetate and chloroacetic acid:
1.- Monochloroacetic acid: experimental results: Two studies with Scenedesmus subspicatus were independently performed at two different laboratories. The obtained results for biomass and growth were within the same range, i.e. 25-28 μg/l for biomass and 30-70 μg/l for growth (48-72 hour EC50-values). In the 72 -hour study, the NOEC is 0.0058 mg/l and in the 48 -hour study, the NOEC is 0.007 mg/l (based on biomass) and 0.014 mg/l (based on growth rate). These results, which are below 1 mg/l, support the classification of the substance monochloroacetic acid as Hazardous for the Aquatic Environment, Acute Category 1. The substance is classified in the harmonised list of classification and labelling (CLP Regulation) as Hazardous for the Aquatic Environment, Acute Category 1.
2.- Methyl chloroacetate: Based on the QSAR prediction for the analogue ethyl chloroacetate (48 h EC50 = 20.8 mg/l; Multicase model; Danish EPA) and the molecular weights, the read-across approach is applied and for algae the EC50 for methyl chloroacetate is calculated to be 18.33 mg/l.
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