Registration Dossier
Registration Dossier
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EC number: 277-955-7 | CAS number: 74664-50-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the irritation potential. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.
Data source
Reference
- Reference Type:
- other: information from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Similar substance 01
- IUPAC Name:
- Similar substance 01
- Test material form:
- solid
Constituent 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: lack of details; data from migrated NONS file
Any other information on results incl. tables
Moderate conjunctival response with chemosis noted at 1 hour and redness at 24 hours. By 72 hours only slight conjunctival redness in one animal. The substance is not classifiable as an eye irritant.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- Not irritant.
- Executive summary:
Method
Test conducted according to OECD guideline 405. No details are available. Information derived from migrated NONS file, as per Article 25(3) request with permission to refer granted by ECHA.
Results
Moderate conjunctival response with chemosis noted at 1 hour and redness at 24 hours. By 72 hours only slight conjunctival redness in one animal.
Not irritant.
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