Registration Dossier
Registration Dossier
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EC number: 204-569-8 | CAS number: 122-72-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is frompeer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on 3-phenylpropyl acetate
- Author:
- D. McGinty, C.S. Letizia, A.M. Api
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S457–S461
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study was conducted on rats for the test compound 3- Phenylpropyl acetate
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 3-phenylpropyl acetate
- EC Number:
- 204-569-8
- EC Name:
- 3-phenylpropyl acetate
- Cas Number:
- 122-72-5
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 3-phenylpropyl acetate
- Reference substance name:
- 3- Phenylpropyl acetate
- IUPAC Name:
- 3- Phenylpropyl acetate
- Test material form:
- other: colorless liquid
- Details on test material:
- - Name of test material (as cited in study report):3- Phenylpropyl acetate- Molecular formula (if other than submission substance):C11H14O2- Molecular weight (if other than submission substance):178.23 g/mol- Substance type:Organic- Physical state:colorless liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 2220, 3330, 5000 and 7000 mg/Kg
- No. of animals per sex per dose:
- Total: 40 2220 mg/kg :10 rats3330 mg/kg :10 rats5000 mg/kg :10 rats7000 mg/kg :10 rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: clinical signs and mortality
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 840 - 5 560
- Remarks on result:
- other: No effect on survival and clinical sign
- Mortality:
- 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing
- Clinical signs:
- other: When treated with 3330 and 7000 mg/kg, piloerection were observed in treated rats. When treated with 5000 and 7000 mg/kg,depression and a negative righting reflex were observed in treated rats.
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
Dose (mg/Kg) | Mortality |
2220 | 0 |
3330 | 2 |
5000 | 6 |
7000 | 9 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
- Executive summary:
In a acute oral toxicity study, group of 10 rats were treated with 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
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