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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is frompeer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance material review on 3-phenylpropyl acetate
Author:
D. McGinty, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S457–S461

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity study was conducted on rats for the test compound 3- Phenylpropyl acetate
GLP compliance:
no
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-phenylpropyl acetate
EC Number:
204-569-8
EC Name:
3-phenylpropyl acetate
Cas Number:
122-72-5
Molecular formula:
C11H14O2
IUPAC Name:
3-phenylpropyl acetate
Constituent 2
Reference substance name:
3- Phenylpropyl acetate
IUPAC Name:
3- Phenylpropyl acetate
Test material form:
other: colorless liquid
Details on test material:
- Name of test material (as cited in study report):3- Phenylpropyl acetate- Molecular formula (if other than submission substance):C11H14O2- Molecular weight (if other than submission substance):178.23 g/mol- Substance type:Organic- Physical state:colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2220, 3330, 5000 and 7000 mg/Kg
No. of animals per sex per dose:
Total: 40 2220 mg/kg :10 rats3330 mg/kg :10 rats5000 mg/kg :10 rats7000 mg/kg :10 rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: clinical signs and mortality
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 700 mg/kg bw
Based on:
test mat.
95% CL:
3 840 - 5 560
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing
Clinical signs:
other: When treated with 3330 and 7000 mg/kg, piloerection were observed in treated rats. When treated with 5000 and 7000 mg/kg,depression and a negative righting reflex were observed in treated rats.
Gross pathology:
No data available
Other findings:
No data available

Any other information on results incl. tables

Dose (mg/Kg)

Mortality

2220

0

3330

2

5000

6

7000

9

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
Executive summary:

In a acute oral toxicity study, group of 10 rats were treated with 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.