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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
other information

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Haemoglobin adducts from aromatic amines and tobacco-specific nitrosamines in pregnant smoking and non-smoking women
Author:
Branner B, Kutzer C, Zwickenpflug W, Scherer G, Heller WD, Richter E
Year:
1998
Bibliographic source:
Biomarkers 3, 35-47
Reference Type:
publication
Title:
Hemoglobin adducts of anomatic amines: association with smoking status and type of tobacco
Author:
Bryant MS, Vineis P, Skipper PL, Tannenbaum StR
Year:
1988
Bibliographic source:
Proc Natl Acad Sci (USA) 85, 9788-9791
Reference Type:
publication
Title:
Determination of human exposure to carcinogenic aromatic amines from hemoglobin adducts in selected population groups
Author:
Skipper PL, Bryant MS, Tannenbaum StR
Year:
1988
Bibliographic source:
Proc Int Conf Carcinog Mutagen Responses p 65-71

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
not applicable
Principles of method if other than guideline:
Blood samples were collected from voluteers (active smoking and non-smoking) to determine hemoglobin adducts with aromatic amines(e.g. m-toluidine).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
m-toluidine
EC Number:
203-583-1
EC Name:
m-toluidine
Cas Number:
108-44-1
Molecular formula:
C7H9N
IUPAC Name:
m-toluidine
Details on test material:
constituent of tabacco smoke :no further data

Method

Subjects:
volunteers (male and females)
Route of exposure:
inhalation
Reason of exposure:
other: intentional, non-occupational

Results and discussion

Clinical signs:
no data
Results of examinations:
There was no significant difference in the adduct level between active smoking and non-smoking volunteers.
Adduct levels revaled to be higher using black tabacco than blond tabacco.

Any other information on results incl. tables

There was no significant difference in the adduct level between active smoking and non-smoking volunteers.

Adduct levels revaled to be higher using black tabacco than blond tabacco.

Applicant's summary and conclusion

Conclusions:
There was no significant difference in the adduct level between active smoking and non-smoking volunteers.
Adduct levels revaled to be higher using black tabacco than blond tabacco.

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